A cure for Asthma: Not too far away!

Asthma is a common chronic inflammatory disease which can be found nowadays all around the world. Main characteristic of this disease is the Airway hyperresponsiveness and inflammation which results symptoms including wheezing, coughing, chest tightness, and shortness of breath.

Asthma attack
Figure A shows the location of the lungs and airways in the body. Figure B shows a cross-section of a normal airway. Figure C shows a cross-section of an airway during asthma symptoms. (Source- United States-National Institute of Health)

Asthma is thought to be caused by a combination of genetic and environmental factors but scientists had been unable to find the exact root cause of this sometimes deadly disease. But creating a breakthrough in Asthma research a team of scientists from the Cardiff University working in collaboration with scientists at King’s College London and the Mayo Clinic (USA) have been able to find the type of cells which are responsible for causing Asthma.

In their research paper published in Science Translational Medicine journal, researchers, , describe the previously unproven role of the calcium sensing receptor (CaSR) in causing asthma, the disease which affects 300 million people worldwide.

These Calcium Sensing Reseptors were once the target for Osteoporosis Research as Scientists were trying to increase the strength of the bones by inducing the release of an anabolic hormone. To do that they used a type of drugs called calcilytics which later proven to be unsuccessful.

Professor Daniela Riccardi
Professor Daniela Riccardi (Source – Cardiff University Web)

 

But this latest finding have given the researchers a unique opportunity to re use this drug for Asthma treatments. Speaking to Cardiff university website Professor Daniela Riccardi says, “If we can prove that calcilytics are safe when administered directly to the lung in people, then in five years we could be in a position to treat patients and potentially stop asthma from happening in the first place,”.

The findings could also create the way for new treatments for few other similar diseases like chronic obstructive pulmonary disease (COPD) and chronic bronchitis, for which currently there exists no cure.

The research was published in the journal Science Translational Medicine and now available in this link.

4 thoughts on “A cure for Asthma: Not too far away!

  • September 29, 2017 at 8:12 am
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    Asthma incidence is continuing to rise in Sri Lanka. It is a significant factor in the increased morbidity rates due to respiratory disorders in children.
    https://goo.gl/2qJ8K7

    • October 2, 2017 at 4:53 am
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      Please send us a little writup on this for the website and the print edition, for more information please call 0716855379-sisira

  • May 29, 2015 at 4:26 am
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    @Joshep Sir, Over estimation is something common nowadays with most of the research out comes. For an example you can see many success stories on cancer treatment findings, But we as you said we can’t neglect these findings directly as these might be the starting steps of a major breakthrough.

    BTW, Thank you very much for the comment as we consider your little input in our story as a very big push/encouragement to continue our way forward.

  • May 28, 2015 at 1:16 pm
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    The research cited above is a great work by reputed researchers in the area. However, to say that this finding will lead to asthma cure in 5 years is an over statement (or more precisely, I would say this the outcome of non-scientists handling the research data to publicize their institution). Numerous studies on mouse models and using cells/tissues grown in petri dish have identified hundreds of molecules that explain the development of asthma. Certainly, all these targets bring us a bit closer to understanding the pathogenesis of the disease. But, unfortunately and not surprisingly, none of these studies lead to the “cure” of asthma. This is because asthma is a condition with multiple origins and diverse in its molecular and clinical characteristics: so one size does not fit all. The reductionist approaches, however cutting-edge they are, are just models. Most of the times in biology, the findings from a model do not translate well in the real life situations. These are my humble thoughts, before anyone getting a false hope about getting their asthma “cured” in the next five years.

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