Asthma is a common chronic inflammatory disease which can be found nowadays all around the world. Main characteristic of this disease is the Airway hyperresponsiveness and inflammation which results symptoms including wheezing, coughing, chest tightness, and shortness of breath.
Asthma is thought to be caused by a combination of genetic and environmental factors but scientists had been unable to find the exact root cause of this sometimes deadly disease. But creating a breakthrough in Asthma research a team of scientists from the Cardiff University working in collaboration with scientists at King’s College London and the Mayo Clinic (USA) have been able to find the type of cells which are responsible for causing Asthma.
In their research paper published in Science Translational Medicine journal, researchers, , describe the previously unproven role of the calcium sensing receptor (CaSR) in causing asthma, the disease which affects 300 million people worldwide.
These Calcium Sensing Reseptors were once the target for Osteoporosis Research as Scientists were trying to increase the strength of the bones by inducing the release of an anabolic hormone. To do that they used a type of drugs called calcilytics which later proven to be unsuccessful.
But this latest finding have given the researchers a unique opportunity to re use this drug for Asthma treatments. Speaking to Cardiff university website Professor Daniela Riccardi says, “If we can prove that calcilytics are safe when administered directly to the lung in people, then in five years we could be in a position to treat patients and potentially stop asthma from happening in the first place,”.
The findings could also create the way for new treatments for few other similar diseases like chronic obstructive pulmonary disease (COPD) and chronic bronchitis, for which currently there exists no cure.
The research was published in the journal Science Translational Medicine and now available in this link.